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KMID : 0378019900330090109
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New Medical Journal
1990 Volume.33 No. 9 p.109 ~ p.112
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The Clinical Effects of Oral Administration of UFT in Advanced or Recurrent Gastrointestinal Tract Cancer
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Abstract
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UFT is a new anticancer drug consisting of futraful(FT) and uracil in the molar ratio of 1:4. Its basic rationale has been known that the concentration of 5-FU inhuman carcinomatous tissues after the administration of this compound (UFT) is maintained longer than in non-carcinomatous tissues. While the blood level of 5-FU is comparatively low and the compound is retained for a shorter time.
UFT administration enhances the anticancer effect of 5-FU as the Uracil interfere the degradation of 5-FU.
In this paper authors investigate the effects, side effects of oral administration of UFT in 20 patients of advanced or recurrent colorectal and gastric cancer. The obtained results were as follows ;
1. The patients status before UFT administration were PSG 1 in 80% of patients which revealed relatively good general conditions of patients.
2. The side effects of UFT were grade 1 in 95% of patients and only 5% of grade +++ who was discontinued of administration of UFT.
3. The effects of drug(UFT) were "response" in 25%, "stable" in 35% and "progress" in 40% of patients after two months oral administration.
Conclusively, the oral administration of UFT in advanced or recurrent gastric or colorectal cancer patients revealed "response" in 25% of patients with a few, mild side effects. But further evaluation with large sample of patients and longer administration is recommended.
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KEYWORD
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